NAL VON MINDEN Micropoint qLabs VET Recalcification kit

Blood coagulation is an extremely complex system. A wide range of mechanisms ensure that an injury to a blood vessel does not result in uncontrolled blood loss. Haemostasis is a vital process that stops bleeding caused by injuries to blood vessels.
Primary, cellular haemostasis (also known as the initial cessation of bleeding) involves thrombocytes (platelets), the endothelial cells and smooth muscle cells of the affected blood vessel, as well as the tissue outside the vessel. In secondary, plasmatic haemostasis (also known as blood coagulation), this still loose closure of the vessel is stabilised by the formation of fibrin threads. Coagulation factors and the formation of fibrin from fibrinogen play an important role in this process.
The plasmatic coagulation cascade is further divided into an intrinsic and an extrinsic system. However, increasing cross-interactions between the two systems are becoming apparent. Put simply, the intrinsic pathway relates to damage within the vascular system without involvement of surrounding tissue and proceeds via factors XII, XI, IX and VIII to the common pathway. In the extrinsic pathway, the triggering factor is usually damaged endothelium due to external trauma and blood escaping from the vascular system. Here, activation of factor VII leads into the common pathway. With activation of factor X, after the two systems have proceeded separately, coagulation continues via the common pathway involving factors V, II and I.